Experimental Cerebral Infarction. I. Selective Segmental Occlusion of Intracranial Arteries in the Dog

Experimental cerebral infarction. I. Selective segmental occlusion of intracranial arteries in the dog.

Experimental Cerebral Infarction . . Selective Segmental Occlusion of ntracranial Arteries in the Dog

Experimental Cerebral Infarction. I. Selective Segmental Occlusion of Intracranial Arteries in the Dog • 1. Cylinders of silicone rubber can be molded to any desired diameter and cut to length, yielding a highly pigmented, radio-opaque, elastic bolus suitable for intravascular injection and embolization. 2. Emboli of this type can be localized by x-ray in vivo and at post mortem for clinicopath...

Production of various models of cerebral infarction in the dog by means of occlusion of intracranial trunk arteries.

Using the dog, which has been believed unsuitable for research on brain infarction because of an extensive collateral cerebral circulation, we have succeeded in producing at will ischemic foci, as determined from post-occlusion carbon perfusion, in the thalamus, cerebral mantle or entire cerebral hemisphere. This has been achieved by occlusion of various combinations of cerebral vessels at the ...

Extracranial-intracranial bypass in experimental cerebral infarction in dogs.

Unilateral permanent occlusion of the proximal part of the middle cerebral artery (MCA) was performed in 24 dogs. End-to-side anastomosis of the maxillary artery (MA) and a branch of the MCA on the occluded side was made 4 hours later in 8 dogs (prompt bypass group), and 3 weeks later in 5 dogs (delayed bypass group) using an operating microscope. The other 11 dogs without MA/MCA anastomosis we...

Inhibition of Angiotensin-Converting Enzyme Reduces Cerebral Infarction Size in Experimental-Induced Focal Cerebral Ischemia in the Rat

Background: The role of Renin Angiotensin System (RAS) in ischemic/reperfusion (I/R) injuries is not fully elucidated. Furthermore, it is not clear whether inhibition of RAS by Angiotensin-Converting Enzyme (ACE) inhibitors has beneficial effects in terms of protecting the brain from I/R injuries. In this study enalapril is used as an ACE inhibitor to evaluate the role of RAS in I/R injuries in...